TBL1XR1-STAT3 Fusion FISH Probe
The TBL1XR1-STAT3 Fusion FISH Probe is used to confirm a fusion of the TBL1XR1 and STAT3 genes. The fusion of the TBL1XR1 and STAT3 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBL1XR1-STAT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-STAT3-20-AQAQ | 20 (40 μL) | 200 μL |
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STAT3 Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Gene Name: Signal Transducer And Activator Of Transcription 3
Chromosome: CHR17: 40465342 -40540513
Locus: 17q21.2
TBL1XR1 Gene Summary
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Name: Transducin Beta Like 1 X-linked Receptor 1
Chromosome: CHR3: 176738541 -176915048
Locus: 3q26.32
Gene Diseases
The TBL1XR1 STAT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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