TBL1XR1-ROCK1 Fusion FISH Probe
The TBL1XR1-ROCK1 Fusion FISH Probe is used to confirm a fusion of the TBL1XR1 and ROCK1 genes. The fusion of the TBL1XR1 and ROCK1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBL1XR1-ROCK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ROCK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
TBL1XR1 Gene Summary
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Name: Transducin Beta Like 1 X-linked Receptor 1
Chromosome: CHR3: 176738541 -176915048
Locus: 3q26.32
Gene Diseases
The TBL1XR1 ROCK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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