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TBL1XR1-RET Fusion FISH Probe

The TBL1XR1-RET Fusion FISH Probe is used to confirm a fusion of the TBL1XR1 and RET genes. The fusion of the TBL1XR1 and RET genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TBL1XR1-RET-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TBL1XR1-RET-20-RERE 20 (40 μL) 200 μL
TBL1XR1-RET-20-REOR 20 (40 μL) 200 μL
TBL1XR1-RET-20-REGO 20 (40 μL) 200 μL
TBL1XR1-RET-20-REGR 20 (40 μL) 200 μL
TBL1XR1-RET-20-REAQ 20 (40 μL) 200 μL
TBL1XR1-RET-20-ORRE 20 (40 μL) 200 μL
TBL1XR1-RET-20-OROR 20 (40 μL) 200 μL
TBL1XR1-RET-20-ORGO 20 (40 μL) 200 μL
TBL1XR1-RET-20-ORAQ 20 (40 μL) 200 μL
TBL1XR1-RET-20-GORE 20 (40 μL) 200 μL
TBL1XR1-RET-20-GOOR 20 (40 μL) 200 μL
TBL1XR1-RET-20-GOGO 20 (40 μL) 200 μL
TBL1XR1-RET-20-GOGR 20 (40 μL) 200 μL
TBL1XR1-RET-20-GOAQ 20 (40 μL) 200 μL
TBL1XR1-RET-20-GRRE 20 (40 μL) 200 μL
TBL1XR1-RET-20-GROR 20 (40 μL) 200 μL
TBL1XR1-RET-20-GRGO 20 (40 μL) 200 μL
TBL1XR1-RET-20-GRGR 20 (40 μL) 200 μL
TBL1XR1-RET-20-GRAQ 20 (40 μL) 200 μL
TBL1XR1-RET-20-AQRE 20 (40 μL) 200 μL
TBL1XR1-RET-20-AQOR 20 (40 μL) 200 μL
TBL1XR1-RET-20-AQGO 20 (40 μL) 200 μL
TBL1XR1-RET-20-AQGR 20 (40 μL) 200 μL
TBL1XR1-RET-20-AQAQ 20 (40 μL) 200 μL

RET Gene Summary

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

Gene Name: Ret Proto-oncogene

Chromosome: CHR10: 43572516 -43625797

Locus: 10q11.21

TBL1XR1 Gene Summary

This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]

Gene Name: Transducin Beta Like 1 X-linked Receptor 1

Chromosome: CHR3: 176738541 -176915048

Locus: 3q26.32

Gene Diseases

The TBL1XR1 RET Fusion has been associated with the following diseases:

Disease Name
Thyroid Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.