TBL1XR1-CACNA1C Fusion FISH Probe
The TBL1XR1-CACNA1C Fusion FISH Probe is used to confirm a fusion of the TBL1XR1 and CACNA1C genes. The fusion of the TBL1XR1 and CACNA1C genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBL1XR1-CACNA1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-CACNA1C-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1C Gene Summary
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 C
Chromosome: CHR12: 2162415 -2807115
Locus: 12p13.33
TBL1XR1 Gene Summary
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Name: Transducin Beta Like 1 X-linked Receptor 1
Chromosome: CHR3: 176738541 -176915048
Locus: 3q26.32
Gene Diseases
The TBL1XR1 CACNA1C Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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