TBL1XR1-ATG7 Fusion FISH Probe
The TBL1XR1-ATG7 Fusion FISH Probe is used to confirm a fusion of the TBL1XR1 and ATG7 genes. The fusion of the TBL1XR1 and ATG7 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBL1XR1-ATG7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1XR1-ATG7-20-AQAQ | 20 (40 μL) | 200 μL |
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ATG7 Gene Summary
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: Autophagy Related 7
Chromosome: CHR3: 11314009 -11599139
Locus: 3p25.3
TBL1XR1 Gene Summary
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Name: Transducin Beta Like 1 X-linked Receptor 1
Chromosome: CHR3: 176738541 -176915048
Locus: 3q26.32
Gene Diseases
The TBL1XR1 ATG7 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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