TBL1X-GPR143 Fusion FISH Probe
The TBL1X-GPR143 Fusion FISH Probe is used to confirm a fusion of the TBL1X and GPR143 genes. The fusion of the TBL1X and GPR143 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBL1X-GPR143-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1X-GPR143-20-AQAQ | 20 (40 μL) | 200 μL |
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GPR143 Gene Summary
This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Gene Name: G Protein-coupled Receptor 143
Chromosome: CHRX: 9693452 -9734005
Locus: Xp22.2
TBL1X Gene Summary
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]
Gene Name: Transducin Beta Like 1 X-linked
Chromosome: CHRX: 9431334 -9687780
Locus: Xp22.31-p22.2
Gene Diseases
The TBL1X GPR143 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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