TBL1X-CASK Fusion FISH Probe
The TBL1X-CASK Fusion FISH Probe is used to confirm a fusion of the TBL1X and CASK genes. The fusion of the TBL1X and CASK genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBL1X-CASK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-RERE | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-REOR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-REGO | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-REGR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-REAQ | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-ORRE | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-OROR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-ORGO | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GORE | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GOOR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GOGO | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GOGR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GRRE | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GROR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GRGO | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GRGR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-AQRE | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-AQOR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-AQGO | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-AQGR | 20 (40 μL) | 200 μL |
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| TBL1X-CASK-20-AQAQ | 20 (40 μL) | 200 μL |
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TBL1X Gene Summary
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]
Gene Name: Transducin Beta Like 1 X-linked
Chromosome: CHRX: 9431334 -9687780
Locus: Xp22.31-p22.2
CASK Gene Summary
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Gene Name: Calcium/calmodulin Dependent Serine Protein Kinase
Chromosome: CHRX: 41374188 -41782287
Locus: Xp11.4
Gene Diseases
The TBL1X CASK Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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