TBK1-GRIP1 Fusion FISH Probe
The TBK1-GRIP1 Fusion FISH Probe is used to confirm a fusion of the TBK1 and GRIP1 genes. The fusion of the TBK1 and GRIP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TBK1-GRIP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-RERE | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-REOR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-REGO | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-REGR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-REAQ | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-ORRE | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-OROR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-ORGO | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GORE | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GOOR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GOGO | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GOGR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GRRE | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GROR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GRGO | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GRGR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-AQRE | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-AQOR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-AQGO | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-AQGR | 20 (40 μL) | 200 μL |
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| TBK1-GRIP1-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIP1 Gene Summary
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Gene Name: Glutamate Receptor Interacting Protein 1
Chromosome: CHR12: 66741210 -67072925
Locus: 12q14.3
TBK1 Gene Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]
Gene Name: TANK Binding Kinase 1
Chromosome: CHR12: 64845839 -64895899
Locus: 12q14.2
Gene Diseases
The TBK1 GRIP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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