TAX1BP3-C17ORF85 Fusion FISH Probe
The TAX1BP3-C17ORF85 Fusion FISH Probe is used to confirm a fusion of the TAX1BP3 and C17ORF85 genes. The fusion of the TAX1BP3 and C17ORF85 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAX1BP3-C17ORF85-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-RERE | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-REOR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-REGO | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-REGR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-REAQ | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-ORRE | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-OROR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-ORGO | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GORE | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GOOR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GOGO | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GOGR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GRRE | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GROR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GRGO | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GRGR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-AQRE | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-AQOR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-AQGO | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-AQGR | 20 (40 μL) | 200 μL |
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| TAX1BP3-C17ORF85-20-AQAQ | 20 (40 μL) | 200 μL |
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TAX1BP3 Gene Summary
This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Gene Name: Tax1 Binding Protein 3
Chromosome: CHR17: 3566186 -3571973
Locus: 17p13.2
Gene Diseases
The TAX1BP3 C17ORF85 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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