TAX1BP1-GPX4 Fusion FISH Probe
The TAX1BP1-GPX4 Fusion FISH Probe is used to confirm a fusion of the TAX1BP1 and GPX4 genes. The fusion of the TAX1BP1 and GPX4 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAX1BP1-GPX4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-RERE | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-REOR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-REGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-REGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-REAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-ORRE | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-OROR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-ORGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GORE | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GOOR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GOGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GOGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GRRE | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GROR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GRGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GRGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-AQRE | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-AQOR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-AQGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-AQGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-GPX4-20-AQAQ | 20 (40 μL) | 200 μL |
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GPX4 Gene Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Gene Name: Glutathione Peroxidase 4
Chromosome: CHR19: 1103935 -1106787
Locus: 19p13.3
TAX1BP1 Gene Summary
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Gene Name: Tax1 Binding Protein 1
Chromosome: CHR7: 27778991 -27869386
Locus: 7p15.2
Gene Diseases
The TAX1BP1 GPX4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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