TAX1BP1-CHN2 Fusion FISH Probe
The TAX1BP1-CHN2 Fusion FISH Probe is used to confirm a fusion of the TAX1BP1 and CHN2 genes. The fusion of the TAX1BP1 and CHN2 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAX1BP1-CHN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-RERE | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-REOR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-REGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-REGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-REAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-ORRE | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-OROR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-ORGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GORE | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GOOR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GOGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GOGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GRRE | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GROR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GRGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GRGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-AQRE | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-AQOR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-AQGO | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-AQGR | 20 (40 μL) | 200 μL |
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| TAX1BP1-CHN2-20-AQAQ | 20 (40 μL) | 200 μL |
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CHN2 Gene Summary
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Chimerin 2
Chromosome: CHR7: 29234120 -29553944
Locus: 7p14.3
TAX1BP1 Gene Summary
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Gene Name: Tax1 Binding Protein 1
Chromosome: CHR7: 27778991 -27869386
Locus: 7p15.2
Gene Diseases
The TAX1BP1 CHN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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