TARS2-VPS45 Fusion FISH Probe
The TARS2-VPS45 Fusion FISH Probe is used to confirm a fusion of the TARS2 and VPS45 genes. The fusion of the TARS2 and VPS45 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TARS2-VPS45-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-RERE | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-REOR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-REGO | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-REGR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-REAQ | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-ORRE | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-OROR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-ORGO | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-ORAQ | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GORE | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GOOR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GOGO | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GOGR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GOAQ | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GRRE | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GROR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GRGO | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GRGR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-GRAQ | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-AQRE | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-AQOR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-AQGO | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-AQGR | 20 (40 μL) | 200 μL |
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| TARS2-VPS45-20-AQAQ | 20 (40 μL) | 200 μL |
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VPS45 Gene Summary
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Vacuolar Protein Sorting 45 Homolog
Chromosome: CHR1: 150039341 -150117505
Locus: 1q21.2
TARS2 Gene Summary
This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]
Gene Name: Threonyl-tRNA Synthetase 2, Mitochondrial (putative)
Chromosome: CHR1: 150459919 -150479749
Locus: 1q21.2
Gene Diseases
The TARS2 VPS45 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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