TAPT1-LDB2 Fusion FISH Probe
The TAPT1-LDB2 Fusion FISH Probe is used to confirm a fusion of the TAPT1 and LDB2 genes. The fusion of the TAPT1 and LDB2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAPT1-LDB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-RERE | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-REOR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-REGO | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-REGR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-REAQ | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-ORRE | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-OROR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-ORGO | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GORE | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GOOR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GOGO | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GOGR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GRRE | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GROR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GRGO | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GRGR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-AQRE | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-AQOR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-AQGO | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-AQGR | 20 (40 μL) | 200 μL |
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| TAPT1-LDB2-20-AQAQ | 20 (40 μL) | 200 μL |
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LDB2 Gene Summary
The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: LIM Domain Binding 2
Chromosome: CHR4: 16503164 -16900424
Locus: 4p15.32
TAPT1 Gene Summary
This gene encodes a highly conserved protein that localizes to the centrosome and/or ciliary basal body. Mutations in this gene disrupt Golgi morphology and trafficking and normal primary cilium formation and these mutations are congenitally manifested by severe undermineralization of the intra-uterine skeleton. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. In mouse, this gene is thought to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. [provided by RefSeq, Jan 2017]
Gene Name: Transmembrane Anterior Posterior Transformation 1
Chromosome: CHR4: 16162127 -16228161
Locus: 4p15.32
Gene Diseases
The TAPT1 LDB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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