TAP2-VARS Fusion FISH Probe
The TAP2-VARS Fusion FISH Probe is used to confirm a fusion of the TAP2 and VARS genes. The fusion of the TAP2 and VARS genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAP2-VARS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-RERE | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-REOR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-REGO | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-REGR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-REAQ | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-ORRE | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-OROR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-ORGO | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GORE | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GOOR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GOGO | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GOGR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GRRE | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GROR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GRGO | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GRGR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-AQRE | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-AQOR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-AQGO | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-AQGR | 20 (40 μL) | 200 μL |
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| TAP2-VARS-20-AQAQ | 20 (40 μL) | 200 μL |
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TAP2 Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]
Gene Name: Transporter 2, ATP Binding Cassette Subfamily B Member
Chromosome: CHR6_qbl_hap6: 4021716 -4038655
Locus: 6p21.32
VARS Gene Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]
Gene Name: Valyl-tRNA Synthetase
Chromosome: CHR6_dbb_hap3: 3030878 -3049294
Locus: 6p21.33
Gene Diseases
The TAP2 VARS Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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