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TAOK1-NF1 Fusion FISH Probe

The TAOK1-NF1 Fusion FISH Probe is used to confirm a fusion of the TAOK1 and NF1 genes. The fusion of the TAOK1 and NF1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TAOK1-NF1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
TAOK1-NF1-20-RERE 20 (40 μL) 200 μL
TAOK1-NF1-20-REOR 20 (40 μL) 200 μL
TAOK1-NF1-20-REGO 20 (40 μL) 200 μL
TAOK1-NF1-20-REGR 20 (40 μL) 200 μL
TAOK1-NF1-20-REAQ 20 (40 μL) 200 μL
TAOK1-NF1-20-ORRE 20 (40 μL) 200 μL
TAOK1-NF1-20-OROR 20 (40 μL) 200 μL
TAOK1-NF1-20-ORGO 20 (40 μL) 200 μL
TAOK1-NF1-20-ORAQ 20 (40 μL) 200 μL
TAOK1-NF1-20-GORE 20 (40 μL) 200 μL
TAOK1-NF1-20-GOOR 20 (40 μL) 200 μL
TAOK1-NF1-20-GOGO 20 (40 μL) 200 μL
TAOK1-NF1-20-GOGR 20 (40 μL) 200 μL
TAOK1-NF1-20-GOAQ 20 (40 μL) 200 μL
TAOK1-NF1-20-GRRE 20 (40 μL) 200 μL
TAOK1-NF1-20-GROR 20 (40 μL) 200 μL
TAOK1-NF1-20-GRGO 20 (40 μL) 200 μL
TAOK1-NF1-20-GRGR 20 (40 μL) 200 μL
TAOK1-NF1-20-GRAQ 20 (40 μL) 200 μL
TAOK1-NF1-20-AQRE 20 (40 μL) 200 μL
TAOK1-NF1-20-AQOR 20 (40 μL) 200 μL
TAOK1-NF1-20-AQGO 20 (40 μL) 200 μL
TAOK1-NF1-20-AQGR 20 (40 μL) 200 μL
TAOK1-NF1-20-AQAQ 20 (40 μL) 200 μL

NF1 Gene Summary

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Neurofibromin 1

Chromosome: CHR17: 29421944 -29704695

Locus: 17q11.2

TAOK1 Gene Summary

The TAO Kinase 1 (TAOK1) gene is located on chr17 :27717942-27878921 at 17q11.2.

Gene Name: TAO Kinase 1

Chromosome: CHR17: 27717942 -27878921

Locus: 17q11.2

Gene Diseases

The TAOK1 NF1 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.