TANC1-PKP4 Fusion FISH Probe
The TANC1-PKP4 Fusion FISH Probe is used to confirm a fusion of the TANC1 and PKP4 genes. The fusion of the TANC1 and PKP4 genes has been associated with Ovarian Serous Cystadenocarcinoma, Breast Invasive Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TANC1-PKP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-RERE | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-REOR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-REGO | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-REGR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-REAQ | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-ORRE | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-OROR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-ORGO | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GORE | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GOOR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GOGO | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GOGR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GRRE | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GROR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GRGO | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GRGR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-AQRE | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-AQOR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-AQGO | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-AQGR | 20 (40 μL) | 200 μL |
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| TANC1-PKP4-20-AQAQ | 20 (40 μL) | 200 μL |
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PKP4 Gene Summary
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Gene Name: Plakophilin 4
Chromosome: CHR2: 159313475 -159537940
Locus: 2q24.1
TANC1 Gene Summary
The Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-coil Containing 1 (TANC1) gene is located on chr2 :159825145-160089170 at 2q24.2.
Gene Name: Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-coil Containing 1
Chromosome: CHR2: 159825145 -160089170
Locus: 2q24.2
Gene Diseases
The TANC1 PKP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Breast Invasive Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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