TAGLN-RFWD2 Fusion FISH Probe
The TAGLN-RFWD2 Fusion FISH Probe is used to confirm a fusion of the TAGLN and RFWD2 genes. The fusion of the TAGLN and RFWD2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAGLN-RFWD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-RERE | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-REOR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-REGO | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-REGR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-REAQ | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-ORRE | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-OROR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-ORGO | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GORE | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GOOR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GOGO | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GOGR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GRRE | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GROR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GRGO | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GRGR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-AQRE | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-AQOR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-AQGO | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-AQGR | 20 (40 μL) | 200 μL |
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| TAGLN-RFWD2-20-AQAQ | 20 (40 μL) | 200 μL |
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TAGLN Gene Summary
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
Gene Name: Transgelin
Chromosome: CHR11: 117070039 -117075508
Locus: 11q23.3
RFWD2 Gene Summary
The Ring Finger And WD Repeat Domain 2 (RFWD2) gene is located on chr1 :175913966-176176370 at 1q25.1-q25.2.
Gene Name: Ring Finger And WD Repeat Domain 2
Chromosome: CHR1: 175913966 -176176370
Locus: 1q25.1-q25.2
Gene Diseases
The TAGLN RFWD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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