TAF9-ADAMTS6 Fusion FISH Probe
The TAF9-ADAMTS6 Fusion FISH Probe is used to confirm a fusion of the TAF9 and ADAMTS6 genes. The fusion of the TAF9 and ADAMTS6 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAF9-ADAMTS6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-RERE | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-REOR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-REGO | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-REGR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-REAQ | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-ORRE | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-OROR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-ORGO | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GORE | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GOOR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GOGO | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GOGR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GRRE | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GROR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GRGO | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GRGR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-AQRE | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-AQOR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-AQGO | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-AQGR | 20 (40 μL) | 200 μL |
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| TAF9-ADAMTS6-20-AQAQ | 20 (40 μL) | 200 μL |
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TAF9 Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: TATA-box Binding Protein Associated Factor 9
Chromosome: CHR5: 68647552 -68665840
Locus: 5q13.2
ADAMTS6 Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]
Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 6
Chromosome: CHR5: 64444562 -64777704
Locus: 5q12.3
Gene Diseases
The TAF9 ADAMTS6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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