TAF4-TSHZ2 Fusion FISH Probe
The TAF4-TSHZ2 Fusion FISH Probe is used to confirm a fusion of the TAF4 and TSHZ2 genes. The fusion of the TAF4 and TSHZ2 genes has been associated with Lung Adenocarcinoma, and Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAF4-TSHZ2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-RERE | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-REOR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-REGO | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-REGR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-REAQ | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-ORRE | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-OROR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-ORGO | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GORE | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GOOR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GOGO | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GOGR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GRRE | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GROR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GRGO | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GRGR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-AQRE | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-AQOR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-AQGO | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-AQGR | 20 (40 μL) | 200 μL |
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| TAF4-TSHZ2-20-AQAQ | 20 (40 μL) | 200 μL |
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TAF4 Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
Gene Name: TATA-box Binding Protein Associated Factor 4
Chromosome: CHR20: 60549853 -60640866
Locus: 20q13.33
TSHZ2 Gene Summary
This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Gene Name: Teashirt Zinc Finger Homeobox 2
Chromosome: CHR20: 51588945 -52111869
Locus: 20q13.2
Gene Diseases
The TAF4 TSHZ2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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