TAF3-SVIL Fusion FISH Probe
The TAF3-SVIL Fusion FISH Probe is used to confirm a fusion of the TAF3 and SVIL genes. The fusion of the TAF3 and SVIL genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAF3-SVIL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-RERE | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-REOR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-REGO | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-REGR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-REAQ | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-ORRE | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-OROR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-ORGO | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GORE | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GOOR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GOGO | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GOGR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GRRE | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GROR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GRGO | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GRGR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-AQRE | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-AQOR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-AQGO | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-AQGR | 20 (40 μL) | 200 μL |
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| TAF3-SVIL-20-AQAQ | 20 (40 μL) | 200 μL |
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SVIL Gene Summary
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]
Gene Name: Supervillin
Chromosome: CHR10: 29746276 -30024730
Locus: 10p11.23
TAF3 Gene Summary
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
Gene Name: TATA-box Binding Protein Associated Factor 3
Chromosome: CHR10: 7860672 -8056714
Locus: 10p14
Gene Diseases
The TAF3 SVIL Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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