TAF2-DSCC1 Fusion FISH Probe
The TAF2-DSCC1 Fusion FISH Probe is used to confirm a fusion of the TAF2 and DSCC1 genes. The fusion of the TAF2 and DSCC1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAF2-DSCC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-RERE | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-REOR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-REGO | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-REGR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-REAQ | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-ORRE | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-OROR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-ORGO | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GORE | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GOOR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GOGO | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GOGR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GRRE | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GROR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GRGO | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GRGR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-AQRE | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-AQOR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-AQGO | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-AQGR | 20 (40 μL) | 200 μL |
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| TAF2-DSCC1-20-AQAQ | 20 (40 μL) | 200 μL |
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TAF2 Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
Gene Name: TATA-box Binding Protein Associated Factor 2
Chromosome: CHR8: 120743013 -120845074
Locus: 8q24.12
DSCC1 Gene Summary
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]
Gene Name: DNA Replication And Sister Chromatid Cohesion 1
Chromosome: CHR8: 120846180 -120868170
Locus: 8q24.12
Gene Diseases
The TAF2 DSCC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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