TAF12-RAB6A Fusion FISH Probe
The TAF12-RAB6A Fusion FISH Probe is used to confirm a fusion of the TAF12 and RAB6A genes. The fusion of the TAF12 and RAB6A genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAF12-RAB6A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-RERE | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-REOR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-REGO | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-REGR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-REAQ | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-ORRE | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-OROR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-ORGO | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GORE | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GOOR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GOGO | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GOGR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GRRE | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GROR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GRGO | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GRGR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-AQRE | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-AQOR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-AQGO | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-AQGR | 20 (40 μL) | 200 μL |
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| TAF12-RAB6A-20-AQAQ | 20 (40 μL) | 200 μL |
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RAB6A Gene Summary
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: RAB6A, Member RAS Oncogene Family
Chromosome: CHR11: 73386682 -73472201
Locus: 11q13.4
TAF12 Gene Summary
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: TATA-box Binding Protein Associated Factor 12
Chromosome: CHR1: 28929608 -28969604
Locus: 1p35.3
Gene Diseases
The TAF12 RAB6A Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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