TAF1-ITGB1BP2 Fusion FISH Probe
The TAF1-ITGB1BP2 Fusion FISH Probe is used to confirm a fusion of the TAF1 and ITGB1BP2 genes. The fusion of the TAF1 and ITGB1BP2 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAF1-ITGB1BP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-RERE | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-REOR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-REGO | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-REGR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-REAQ | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-ORRE | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-OROR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-ORGO | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GORE | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GOOR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GOGO | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GOGR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GRRE | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GROR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GRGO | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GRGR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-AQRE | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-AQOR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-AQGO | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-AQGR | 20 (40 μL) | 200 μL |
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| TAF1-ITGB1BP2-20-AQAQ | 20 (40 μL) | 200 μL |
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TAF1 Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]
Gene Name: TATA-box Binding Protein Associated Factor 1
Chromosome: CHRX: 70586113 -70685855
Locus: Xq13.1
ITGB1BP2 Gene Summary
This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017]
Gene Name: Integrin Subunit Beta 1 Binding Protein 2
Chromosome: CHRX: 70521627 -70525204
Locus: Xq13.1
Gene Diseases
The TAF1 ITGB1BP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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