TAB2-KCNU1 Fusion FISH Probe
The TAB2-KCNU1 Fusion FISH Probe is used to confirm a fusion of the TAB2 and KCNU1 genes. The fusion of the TAB2 and KCNU1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAB2-KCNU1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-RERE | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-REOR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-REGO | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-REGR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-REAQ | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-ORRE | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-OROR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-ORGO | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GORE | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GOOR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GOGO | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GOGR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GRRE | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GROR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GRGO | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GRGR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-AQRE | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-AQOR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-AQGO | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-AQGR | 20 (40 μL) | 200 μL |
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| TAB2-KCNU1-20-AQAQ | 20 (40 μL) | 200 μL |
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TAB2 Gene Summary
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2
Chromosome: CHR6: 149639435 -149732747
Locus: 6q25.1
KCNU1 Gene Summary
This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Potassium Calcium-activated Channel Subfamily U Member 1
Chromosome: CHR8: 36641841 -36793643
Locus: 8p11.23
Gene Diseases
The TAB2 KCNU1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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