TAB1-PHF21B Fusion FISH Probe
The TAB1-PHF21B Fusion FISH Probe is used to confirm a fusion of the TAB1 and PHF21B genes. The fusion of the TAB1 and PHF21B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TAB1-PHF21B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-RERE | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-REOR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-REGO | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-REGR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-REAQ | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-ORRE | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-OROR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-ORGO | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-ORAQ | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GORE | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GOOR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GOGO | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GOGR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GOAQ | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GRRE | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GROR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GRGO | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GRGR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-GRAQ | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-AQRE | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-AQOR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-AQGO | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-AQGR | 20 (40 μL) | 200 μL |
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| TAB1-PHF21B-20-AQAQ | 20 (40 μL) | 200 μL |
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TAB1 Gene Summary
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: TGF-beta Activated Kinase 1 (MAP3K7) Binding Protein 1
Chromosome: CHR22: 39795758 -39833132
Locus: 22q13.1
PHF21B Gene Summary
The PHD Finger Protein 21B (PHF21B) gene is located on chr22 :45277042-45405809 at 22q13.31.
Gene Name: PHD Finger Protein 21B
Chromosome: CHR22: 45277042 -45405809
Locus: 22q13.31
Gene Diseases
The TAB1 PHF21B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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