SYTL2-DOK5 Fusion FISH Probe
The SYTL2-DOK5 Fusion FISH Probe is used to confirm a fusion of the SYTL2 and DOK5 genes. The fusion of the SYTL2 and DOK5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYTL2-DOK5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-RERE | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-REOR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-REGO | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-REGR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-REAQ | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-ORRE | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-OROR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-ORGO | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GORE | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GOOR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GOGO | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GOGR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GRRE | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GROR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GRGO | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GRGR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-AQRE | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-AQOR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-AQGO | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-AQGR | 20 (40 μL) | 200 μL |
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| SYTL2-DOK5-20-AQAQ | 20 (40 μL) | 200 μL |
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SYTL2 Gene Summary
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
Gene Name: Synaptotagmin Like 2
Chromosome: CHR11: 85405264 -85522178
Locus: 11q14.1
DOK5 Gene Summary
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: Docking Protein 5
Chromosome: CHR20: 53092265 -53267710
Locus: 20q13.2
Gene Diseases
The SYTL2 DOK5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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