SYT1-PHKB Fusion FISH Probe
The SYT1-PHKB Fusion FISH Probe is used to confirm a fusion of the SYT1 and PHKB genes. The fusion of the SYT1 and PHKB genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYT1-PHKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-RERE | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-REOR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-REGO | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-REGR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-REAQ | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-ORRE | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-OROR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-ORGO | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GORE | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GOOR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GOGO | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GOGR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GRRE | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GROR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GRGO | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GRGR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-AQRE | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-AQOR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-AQGO | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-AQGR | 20 (40 μL) | 200 μL |
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| SYT1-PHKB-20-AQAQ | 20 (40 μL) | 200 μL |
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PHKB Gene Summary
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010]
Gene Name: Phosphorylase Kinase Regulatory Subunit Beta
Chromosome: CHR16: 47495209 -47735434
Locus: 16q12.1
SYT1 Gene Summary
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
Gene Name: Synaptotagmin 1
Chromosome: CHR12: 79257772 -79845788
Locus: 12q21.2
Gene Diseases
The SYT1 PHKB Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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