SYNRG-PIK3R5 Fusion FISH Probe
The SYNRG-PIK3R5 Fusion FISH Probe is used to confirm a fusion of the SYNRG and PIK3R5 genes. The fusion of the SYNRG and PIK3R5 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYNRG-PIK3R5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-RERE | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-REOR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-REGO | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-REGR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-REAQ | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-ORRE | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-OROR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-ORGO | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GORE | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GOOR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GOGO | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GOGR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GRRE | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GROR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GRGO | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GRGR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-AQRE | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-AQOR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-AQGO | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-AQGR | 20 (40 μL) | 200 μL |
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| SYNRG-PIK3R5-20-AQAQ | 20 (40 μL) | 200 μL |
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SYNRG Gene Summary
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Synergin Gamma
Chromosome: CHR17: 35874899 -35969486
Locus: 17q12
PIK3R5 Gene Summary
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Gene Name: Phosphoinositide-3-kinase Regulatory Subunit 5
Chromosome: CHR17: 8782232 -8869024
Locus: 17p13.1
Gene Diseases
The SYNRG PIK3R5 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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