SYNE1-ESR1 Fusion FISH Probe
The SYNE1-ESR1 Fusion FISH Probe is used to confirm a fusion of the SYNE1 and ESR1 genes. The fusion of the SYNE1 and ESR1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYNE1-ESR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-RERE | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-REOR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-REGO | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-REGR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-REAQ | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-ORRE | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-OROR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-ORGO | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GORE | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GOOR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GOGO | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GOGR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GRRE | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GROR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GRGO | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GRGR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-AQRE | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-AQOR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-AQGO | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-AQGR | 20 (40 μL) | 200 μL |
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| SYNE1-ESR1-20-AQAQ | 20 (40 μL) | 200 μL |
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ESR1 Gene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Gene Name: Estrogen Receptor 1
Chromosome: CHR6: 152011630 -152424408
Locus: 6q25.1-q25.2
SYNE1 Gene Summary
This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Spectrin Repeat Containing Nuclear Envelope Protein 1
Chromosome: CHR6: 152442818 -152958534
Locus: 6q25.2
Gene Diseases
The SYNE1 ESR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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