SYNE1-CACNA1C Fusion FISH Probe
The SYNE1-CACNA1C Fusion FISH Probe is used to confirm a fusion of the SYNE1 and CACNA1C genes. The fusion of the SYNE1 and CACNA1C genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYNE1-CACNA1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-RERE | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-REOR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-REGO | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-REGR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-REAQ | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-ORRE | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-OROR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-ORGO | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GORE | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GOOR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GOGO | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GOGR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GRRE | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GROR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GRGO | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GRGR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-AQRE | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-AQOR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-AQGO | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-AQGR | 20 (40 μL) | 200 μL |
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| SYNE1-CACNA1C-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1C Gene Summary
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 C
Chromosome: CHR12: 2162415 -2807115
Locus: 12p13.33
SYNE1 Gene Summary
This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Spectrin Repeat Containing Nuclear Envelope Protein 1
Chromosome: CHR6: 152442818 -152958534
Locus: 6q25.2
Gene Diseases
The SYNE1 CACNA1C Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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