SYMPK-LSM4 Fusion FISH Probe
The SYMPK-LSM4 Fusion FISH Probe is used to confirm a fusion of the SYMPK and LSM4 genes. The fusion of the SYMPK and LSM4 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYMPK-LSM4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-RERE | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-REOR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-REGO | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-REGR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-REAQ | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-ORRE | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-OROR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-ORGO | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GORE | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GOOR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GOGO | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GOGR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GRRE | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GROR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GRGO | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GRGR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-AQRE | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-AQOR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-AQGO | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-AQGR | 20 (40 μL) | 200 μL |
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| SYMPK-LSM4-20-AQAQ | 20 (40 μL) | 200 μL |
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SYMPK Gene Summary
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
Gene Name: Symplekin
Chromosome: CHR19: 46318699 -46366548
Locus: 19q13.32
LSM4 Gene Summary
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: LSM4 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated
Chromosome: CHR19: 18417716 -18434001
Locus: 19p13.11
Gene Diseases
The SYMPK LSM4 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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