SYK-AUH Fusion FISH Probe
The SYK-AUH Fusion FISH Probe is used to confirm a fusion of the SYK and AUH genes. The fusion of the SYK and AUH genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYK-AUH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-RERE | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-REOR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-REGO | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-REGR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-REAQ | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-ORRE | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-OROR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-ORGO | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-ORAQ | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GORE | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GOOR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GOGO | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GOGR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GOAQ | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GRRE | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GROR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GRGO | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GRGR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-GRAQ | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-AQRE | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-AQOR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-AQGO | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-AQGR | 20 (40 μL) | 200 μL |
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| SYK-AUH-20-AQAQ | 20 (40 μL) | 200 μL |
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AUH Gene Summary
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: AU RNA Binding Methylglutaconyl-CoA Hydratase
Chromosome: CHR9: 93976096 -94124206
Locus: 9q22.31
SYK Gene Summary
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: Spleen Associated Tyrosine Kinase
Chromosome: CHR9: 93564011 -93660842
Locus: 9q22.2
Gene Diseases
The SYK AUH Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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