SVIL-RFC5 Fusion FISH Probe
The SVIL-RFC5 Fusion FISH Probe is used to confirm a fusion of the SVIL and RFC5 genes. The fusion of the SVIL and RFC5 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SVIL-RFC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-RERE | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-REOR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-REGO | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-REGR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-REAQ | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-ORRE | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-OROR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-ORGO | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-ORAQ | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GORE | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GOOR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GOGO | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GOGR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GOAQ | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GRRE | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GROR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GRGO | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GRGR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-GRAQ | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-AQRE | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-AQOR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-AQGO | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-AQGR | 20 (40 μL) | 200 μL |
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| SVIL-RFC5-20-AQAQ | 20 (40 μL) | 200 μL |
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RFC5 Gene Summary
This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Replication Factor C Subunit 5
Chromosome: CHR12: 118454505 -118470042
Locus: 12q24.23
SVIL Gene Summary
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]
Gene Name: Supervillin
Chromosome: CHR10: 29746276 -30024730
Locus: 10p11.23
Gene Diseases
The SVIL RFC5 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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