SUN2-GTPBP1 Fusion FISH Probe
The SUN2-GTPBP1 Fusion FISH Probe is used to confirm a fusion of the SUN2 and GTPBP1 genes. The fusion of the SUN2 and GTPBP1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SUN2-GTPBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-RERE | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-REOR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-REGO | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-REGR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-REAQ | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-ORRE | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-OROR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-ORGO | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GORE | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GOOR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GOGO | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GOGR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GRRE | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GROR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GRGO | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GRGR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-AQRE | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-AQOR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-AQGO | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-AQGR | 20 (40 μL) | 200 μL |
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| SUN2-GTPBP1-20-AQAQ | 20 (40 μL) | 200 μL |
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GTPBP1 Gene Summary
This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]
Gene Name: GTP Binding Protein 1
Chromosome: CHR22: 39101806 -39129592
Locus: 22q13.1
SUN2 Gene Summary
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Gene Name: Sad1 And UNC84 Domain Containing 2
Chromosome: CHR22: 39130718 -39152024
Locus: 22q13.1
Gene Diseases
The SUN2 GTPBP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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