SULF2-WFDC3 Fusion FISH Probe
The SULF2-WFDC3 Fusion FISH Probe is used to confirm a fusion of the SULF2 and WFDC3 genes. The fusion of the SULF2 and WFDC3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SULF2-WFDC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-RERE | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-REOR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-REGO | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-REGR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-REAQ | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-ORRE | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-OROR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-ORGO | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GORE | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GOOR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GOGO | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GOGR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GRRE | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GROR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GRGO | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GRGR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-AQRE | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-AQOR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-AQGO | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-AQGR | 20 (40 μL) | 200 μL |
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| SULF2-WFDC3-20-AQAQ | 20 (40 μL) | 200 μL |
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SULF2 Gene Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Gene Name: Sulfatase 2
Chromosome: CHR20: 46286149 -46415360
Locus: 20q13.12
WFDC3 Gene Summary
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: WAP Four-disulfide Core Domain 3
Chromosome: CHR20: 44402846 -44420547
Locus: 20q13.12
Gene Diseases
The SULF2 WFDC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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