STX5-TAF6L Fusion FISH Probe
The STX5-TAF6L Fusion FISH Probe is used to confirm a fusion of the STX5 and TAF6L genes. The fusion of the STX5 and TAF6L genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STX5-TAF6L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-RERE | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-REOR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-REGO | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-REGR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-REAQ | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-ORRE | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-OROR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-ORGO | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-ORAQ | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GORE | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GOOR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GOGO | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GOGR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GOAQ | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GRRE | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GROR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GRGO | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GRGR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-GRAQ | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-AQRE | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-AQOR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-AQGO | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-AQGR | 20 (40 μL) | 200 μL |
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| STX5-TAF6L-20-AQAQ | 20 (40 μL) | 200 μL |
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STX5 Gene Summary
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Syntaxin 5
Chromosome: CHR11: 62574368 -62599560
Locus: 11q12.3
TAF6L Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
Gene Name: TATA-box Binding Protein Associated Factor 6 Like
Chromosome: CHR11: 62538774 -62554813
Locus: 11q12.3
Gene Diseases
The STX5 TAF6L Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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