STRN3-COCH Fusion FISH Probe
The STRN3-COCH Fusion FISH Probe is used to confirm a fusion of the STRN3 and COCH genes. The fusion of the STRN3 and COCH genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STRN3-COCH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-RERE | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-REOR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-REGO | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-REGR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-REAQ | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-ORRE | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-OROR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-ORGO | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-ORAQ | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GORE | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GOOR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GOGO | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GOGR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GOAQ | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GRRE | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GROR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GRGO | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GRGR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-GRAQ | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-AQRE | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-AQOR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-AQGO | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-AQGR | 20 (40 μL) | 200 μL |
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| STRN3-COCH-20-AQAQ | 20 (40 μL) | 200 μL |
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COCH Gene Summary
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
Gene Name: Cochlin
Chromosome: CHR14: 31343740 -31359822
Locus: 14q12
STRN3 Gene Summary
The Striatin 3 (STRN3) gene is located on chr14 :31363004-31495607 at 14q12.
Gene Name: Striatin 3
Chromosome: CHR14: 31363004 -31495607
Locus: 14q12
Gene Diseases
The STRN3 COCH Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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