STK4-TSHZ2 Fusion FISH Probe
The STK4-TSHZ2 Fusion FISH Probe is used to confirm a fusion of the STK4 and TSHZ2 genes. The fusion of the STK4 and TSHZ2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STK4-TSHZ2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-RERE | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-REOR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-REGO | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-REGR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-REAQ | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-ORRE | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-OROR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-ORGO | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-ORAQ | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GORE | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GOOR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GOGO | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GOGR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GOAQ | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GRRE | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GROR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GRGO | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GRGR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-GRAQ | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-AQRE | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-AQOR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-AQGO | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-AQGR | 20 (40 μL) | 200 μL |
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| STK4-TSHZ2-20-AQAQ | 20 (40 μL) | 200 μL |
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STK4 Gene Summary
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Gene Name: Serine/threonine Kinase 4
Chromosome: CHR20: 43595119 -43708593
Locus: 20q13.12
TSHZ2 Gene Summary
This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Gene Name: Teashirt Zinc Finger Homeobox 2
Chromosome: CHR20: 51588945 -52111869
Locus: 20q13.2
Gene Diseases
The STK4 TSHZ2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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