STK24-PDE1A Fusion FISH Probe
The STK24-PDE1A Fusion FISH Probe is used to confirm a fusion of the STK24 and PDE1A genes. The fusion of the STK24 and PDE1A genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STK24-PDE1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-RERE | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-REOR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-REGO | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-REGR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-REAQ | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-ORRE | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-OROR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-ORGO | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GORE | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GOOR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GOGO | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GOGR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GRRE | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GROR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GRGO | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GRGR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-AQRE | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-AQOR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-AQGO | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-AQGR | 20 (40 μL) | 200 μL |
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| STK24-PDE1A-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE1A Gene Summary
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
Gene Name: Phosphodiesterase 1A
Chromosome: CHR2: 183007182 -183387253
Locus: 2q32.1
STK24 Gene Summary
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Serine/threonine Kinase 24
Chromosome: CHR13: 99102454 -99229396
Locus: 13q32.2
Gene Diseases
The STK24 PDE1A Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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