STIM1-ANO9 Fusion FISH Probe
The STIM1-ANO9 Fusion FISH Probe is used to confirm a fusion of the STIM1 and ANO9 genes. The fusion of the STIM1 and ANO9 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STIM1-ANO9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-RERE | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-REOR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-REGO | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-REGR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-REAQ | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-ORRE | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-OROR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-ORGO | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-ORAQ | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GORE | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GOOR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GOGO | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GOGR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GOAQ | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GRRE | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GROR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GRGO | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GRGR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-GRAQ | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-AQRE | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-AQOR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-AQGO | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-AQGR | 20 (40 μL) | 200 μL |
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| STIM1-ANO9-20-AQAQ | 20 (40 μL) | 200 μL |
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STIM1 Gene Summary
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Stromal Interaction Molecule 1
Chromosome: CHR11: 3876932 -4114440
Locus: 11p15.4
ANO9 Gene Summary
The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]
Gene Name: Anoctamin 9
Chromosome: CHR11: 417929 -442011
Locus: 11p15.5
Gene Diseases
The STIM1 ANO9 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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