STAU1-PLCE1 Fusion FISH Probe
The STAU1-PLCE1 Fusion FISH Probe is used to confirm a fusion of the STAU1 and PLCE1 genes. The fusion of the STAU1 and PLCE1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STAU1-PLCE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-RERE | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-REOR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-REGO | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-REGR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-REAQ | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-ORRE | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-OROR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-ORGO | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GORE | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GOOR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GOGO | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GOGR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GRRE | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GROR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GRGO | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GRGR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-AQRE | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-AQOR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-AQGO | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-AQGR | 20 (40 μL) | 200 μL |
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| STAU1-PLCE1-20-AQAQ | 20 (40 μL) | 200 μL |
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STAU1 Gene Summary
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
Gene Name: Staufen Double-stranded RNA Binding Protein 1
Chromosome: CHR20: 47729875 -47804904
Locus: 20q13.13
PLCE1 Gene Summary
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Gene Name: Phospholipase C Epsilon 1
Chromosome: CHR10: 95753745 -96088148
Locus: 10q23.33
Gene Diseases
The STAU1 PLCE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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