STAU1-MRPL4 Fusion FISH Probe
The STAU1-MRPL4 Fusion FISH Probe is used to confirm a fusion of the STAU1 and MRPL4 genes. The fusion of the STAU1 and MRPL4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STAU1-MRPL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-RERE | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-REOR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-REGO | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-REGR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-REAQ | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-ORRE | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-OROR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-ORGO | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-ORAQ | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GORE | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GOOR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GOGO | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GOGR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GOAQ | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GRRE | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GROR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GRGO | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GRGR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-GRAQ | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-AQRE | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-AQOR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-AQGO | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-AQGR | 20 (40 μL) | 200 μL |
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| STAU1-MRPL4-20-AQAQ | 20 (40 μL) | 200 μL |
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STAU1 Gene Summary
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
Gene Name: Staufen Double-stranded RNA Binding Protein 1
Chromosome: CHR20: 47729875 -47804904
Locus: 20q13.13
MRPL4 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L4
Chromosome: CHR19: 10362639 -10370736
Locus: 19p13.2
Gene Diseases
The STAU1 MRPL4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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