STAT5B-STAT3 Fusion FISH Probe
The STAT5B-STAT3 Fusion FISH Probe is used to confirm a fusion of the STAT5B and STAT3 genes. The fusion of the STAT5B and STAT3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STAT5B-STAT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-RERE | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-REOR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-REGO | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-REGR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-REAQ | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-ORRE | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-OROR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-ORGO | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GORE | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GOOR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GOGO | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GOGR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GRRE | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GROR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GRGO | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GRGR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-AQRE | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-AQOR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-AQGO | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-AQGR | 20 (40 μL) | 200 μL |
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| STAT5B-STAT3-20-AQAQ | 20 (40 μL) | 200 μL |
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STAT3 Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Gene Name: Signal Transducer And Activator Of Transcription 3
Chromosome: CHR17: 40465342 -40540513
Locus: 17q21.2
STAT5B Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
Gene Name: Signal Transducer And Activator Of Transcription 5B
Chromosome: CHR17: 40351194 -40428424
Locus: 17q21.2
Gene Diseases
The STAT5B STAT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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