STAT5B-PFAS Fusion FISH Probe
The STAT5B-PFAS Fusion FISH Probe is used to confirm a fusion of the STAT5B and PFAS genes. The fusion of the STAT5B and PFAS genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STAT5B-PFAS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-RERE | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-REOR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-REGO | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-REGR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-REAQ | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-ORRE | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-OROR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-ORGO | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-ORAQ | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GORE | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GOOR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GOGO | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GOGR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GOAQ | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GRRE | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GROR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GRGO | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GRGR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-GRAQ | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-AQRE | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-AQOR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-AQGO | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-AQGR | 20 (40 μL) | 200 μL |
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| STAT5B-PFAS-20-AQAQ | 20 (40 μL) | 200 μL |
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PFAS Gene Summary
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]
Gene Name: Phosphoribosylformylglycinamidine Synthase
Chromosome: CHR17: 8152595 -8173809
Locus: 17p13.1
STAT5B Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
Gene Name: Signal Transducer And Activator Of Transcription 5B
Chromosome: CHR17: 40351194 -40428424
Locus: 17q21.2
Gene Diseases
The STAT5B PFAS Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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