STAT5A-ARNTL2 Fusion FISH Probe
The STAT5A-ARNTL2 Fusion FISH Probe is used to confirm a fusion of the STAT5A and ARNTL2 genes. The fusion of the STAT5A and ARNTL2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STAT5A-ARNTL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-RERE | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-REOR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-REGO | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-REGR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-REAQ | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-ORRE | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-OROR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-ORGO | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GORE | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GOOR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GOGO | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GOGR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GRRE | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GROR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GRGO | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GRGR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-AQRE | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-AQOR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-AQGO | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-AQGR | 20 (40 μL) | 200 μL |
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| STAT5A-ARNTL2-20-AQAQ | 20 (40 μL) | 200 μL |
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STAT5A Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Gene Name: Signal Transducer And Activator Of Transcription 5A
Chromosome: CHR17: 40439564 -40463960
Locus: 17q21.2
ARNTL2 Gene Summary
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator Like 2
Chromosome: CHR12: 27485987 -27573466
Locus: 12p11.23
Gene Diseases
The STAT5A ARNTL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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