STAT1-SUMO1 Fusion FISH Probe
The STAT1-SUMO1 Fusion FISH Probe is used to confirm a fusion of the STAT1 and SUMO1 genes. The fusion of the STAT1 and SUMO1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| STAT1-SUMO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-RERE | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-REOR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-REGO | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-REGR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-REAQ | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-ORRE | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-OROR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-ORGO | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-ORAQ | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GORE | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GOOR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GOGO | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GOGR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GOAQ | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GRRE | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GROR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GRGO | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GRGR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-GRAQ | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-AQRE | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-AQOR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-AQGO | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-AQGR | 20 (40 μL) | 200 μL |
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| STAT1-SUMO1-20-AQAQ | 20 (40 μL) | 200 μL |
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STAT1 Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Signal Transducer And Activator Of Transcription 1
Chromosome: CHR2: 191833761 -191878976
Locus: 2q32.2
SUMO1 Gene Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Small Ubiquitin-like Modifier 1
Chromosome: CHR2: 203070902 -203103322
Locus: 2q33.1
Gene Diseases
The STAT1 SUMO1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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