ST7-MET Fusion FISH Probe
The ST7-MET Fusion FISH Probe is used to confirm a fusion of the ST7 and MET genes. The fusion of the ST7 and MET genes has been associated with Testicular Germ Cell Tumors, Lung Adenocarcinoma, Liver Hepatocellular Carcinoma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ST7-MET-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ST7-MET-20-RERE | 20 (40 μL) | 200 μL |
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| ST7-MET-20-REOR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-REGO | 20 (40 μL) | 200 μL |
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| ST7-MET-20-REGR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-REAQ | 20 (40 μL) | 200 μL |
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| ST7-MET-20-ORRE | 20 (40 μL) | 200 μL |
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| ST7-MET-20-OROR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-ORGO | 20 (40 μL) | 200 μL |
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| ST7-MET-20-ORAQ | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GORE | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GOOR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GOGO | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GOGR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GOAQ | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GRRE | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GROR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GRGO | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GRGR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-GRAQ | 20 (40 μL) | 200 μL |
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| ST7-MET-20-AQRE | 20 (40 μL) | 200 μL |
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| ST7-MET-20-AQOR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-AQGO | 20 (40 μL) | 200 μL |
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| ST7-MET-20-AQGR | 20 (40 μL) | 200 μL |
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| ST7-MET-20-AQAQ | 20 (40 μL) | 200 μL |
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MET Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Gene Name: MET Proto-oncogene, Receptor Tyrosine Kinase
Chromosome: CHR7: 116312458 -116438440
Locus: 7q31.2
ST7 Gene Summary
The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Suppression Of Tumorigenicity 7
Chromosome: CHR7: 116593380 -116870075
Locus: 7q31.2
Gene Diseases
The ST7 MET Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
| Lung Adenocarcinoma |
| Liver Hepatocellular Carcinoma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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