ST6GAL1-PSMC3 Fusion FISH Probe
The ST6GAL1-PSMC3 Fusion FISH Probe is used to confirm a fusion of the ST6GAL1 and PSMC3 genes. The fusion of the ST6GAL1 and PSMC3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ST6GAL1-PSMC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-RERE | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-REOR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-REGO | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-REGR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-REAQ | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-ORRE | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-OROR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-ORGO | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GORE | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GOOR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GOGO | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GOGR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GRRE | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GROR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GRGO | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GRGR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-AQRE | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-AQOR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-AQGO | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-AQGR | 20 (40 μL) | 200 μL |
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| ST6GAL1-PSMC3-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMC3 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
Gene Name: Proteasome 26S Subunit, ATPase 3
Chromosome: CHR11: 47440319 -47448024
Locus: 11p11.2
ST6GAL1 Gene Summary
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: ST6 Beta-galactoside Alpha-2,6-sialyltransferase 1
Chromosome: CHR3: 186648314 -186796341
Locus: 3q27.3
Gene Diseases
The ST6GAL1 PSMC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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