ST14-APLP2 Fusion FISH Probe
The ST14-APLP2 Fusion FISH Probe is used to confirm a fusion of the ST14 and APLP2 genes. The fusion of the ST14 and APLP2 genes has been associated with Uterine Corpus Endometrial Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ST14-APLP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-RERE | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-REOR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-REGO | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-REGR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-REAQ | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-ORRE | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-OROR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-ORGO | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GORE | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GOOR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GOGO | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GOGR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GRRE | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GROR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GRGO | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GRGR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-AQRE | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-AQOR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-AQGO | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-AQGR | 20 (40 μL) | 200 μL |
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| ST14-APLP2-20-AQAQ | 20 (40 μL) | 200 μL |
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APLP2 Gene Summary
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Amyloid Beta Precursor Like Protein 2
Chromosome: CHR11: 129939715 -130014706
Locus: 11q24.3
ST14 Gene Summary
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Gene Name: Suppression Of Tumorigenicity 14
Chromosome: CHR11: 130029681 -130080257
Locus: 11q24.3
Gene Diseases
The ST14 APLP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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