SSRP1-MED19 Fusion FISH Probe
The SSRP1-MED19 Fusion FISH Probe is used to confirm a fusion of the SSRP1 and MED19 genes. The fusion of the SSRP1 and MED19 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SSRP1-MED19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-RERE | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-REOR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-REGO | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-REGR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-REAQ | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-ORRE | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-OROR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-ORGO | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-ORAQ | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GORE | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GOOR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GOGO | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GOGR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GOAQ | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GRRE | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GROR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GRGO | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GRGR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-GRAQ | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-AQRE | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-AQOR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-AQGO | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-AQGR | 20 (40 μL) | 200 μL |
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| SSRP1-MED19-20-AQAQ | 20 (40 μL) | 200 μL |
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SSRP1 Gene Summary
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Name: Structure Specific Recognition Protein 1
Chromosome: CHR11: 57093458 -57103351
Locus: 11q12.1
MED19 Gene Summary
The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: Mediator Complex Subunit 19
Chromosome: CHR11: 57471186 -57479673
Locus: 11q12.1
Gene Diseases
The SSRP1 MED19 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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